RefBasedMI - Reference-Based Imputation for Longitudinal Clinical Trials with
Protocol Deviation
Imputation of missing numerical outcomes for a
longitudinal trial with protocol deviations. The package uses
distinct treatment arm-based assumptions for the unobserved
data, following the general algorithm of Carpenter, Roger, and
Kenward (2013) <doi:10.1080/10543406.2013.834911>, and the
causal model of White, Royes and Best (2020)
<doi:10.1080/10543406.2019.1684308>. Sensitivity analyses to
departures from these assumptions can be done by the Delta
method of Roger. The program uses the same algorithm as the
'mimix' 'Stata' package written by Suzie Cro, with additional
coding for the causal model and delta method. The
reference-based methods are jump to reference (J2R), copy
increments in reference (CIR), copy reference (CR), and the
causal model, all of which must specify the reference treatment
arm. Other methods are missing at random (MAR) and the last
mean carried forward (LMCF). Individual-specific imputation
methods (and their reference groups) can be specified.
